منابع مشابه
Hepatic Aldehyde Oxidase
Previous reports on rabbit liver aldehyde oxidase described the purification and some properties of the enzyme (1) and the differential inhibition of electron transfer to various acceptors (2). The latter study furnished evidence for the participation of several electron carriers in the internal electron transport sequence of the enzyme. The present communication summarizes the results of studi...
متن کاملDaily Rhythm in Hepatic and Renal Aldehyde Oxidase and Xanthine Oxidase in Male and Female Uromastyx microlepis
The activities of aldehyde oxidase and xanthine oxidase were determined in partially purified preparations from livers and kidneys of male and female Dhubb, Uromastyx microlepis, four times daily at equal intervals. The maximum activity of male and female hepatic aldehyde oxidase appeared at 2100 h, whereas the minimum activity was observed at 0300 h, using phthalazine and 3-methylisoquinoline ...
متن کاملEvaluation of rhesus monkey and guinea pig hepatic cytosol fractions as models for human aldehyde oxidase.
Aldehyde oxidase (AOX) is a cytosolic enzyme expressed across a wide range of species, including guinea pig and rhesus monkey. These species are believed to be the best preclinical models for studying human AOX-mediated metabolism. We compared AOX activity in rhesus monkeys, guinea pigs, and humans using phthalazine and N-[2-(dimethylamino)ethyl]acridone-4-carboxamide (DACA) as substrates and r...
متن کاملPolygenic control of aldehyde oxidase in Drosophila.
HEN extracts of wild-type Drosophila are electrophoresed on agar gels and the gels stained with a tetrazolium solution containing benzaldehyde, a formazan band is formed at a location not identical to the xanthine dehydrogenase (XDH) band ( COURTRIGHT 1966a). This was a surprising observation since benzaldehyde has been reported to serve as a substrate for XDH (GLASSMAN and MITCHELL 1959a). Sin...
متن کاملAldehyde oxidase activity in fresh human skin.
Human aldehyde oxidase (AO) is a molybdoflavoenzyme that commonly oxidizes azaheterocycles in therapeutic drugs. Although high metabolic clearance by AO resulted in several drug failures, existing in vitro-in vivo correlations are often poor and the extrahepatic role of AO practically unknown. This study investigated enzymatic activity of AO in fresh human skin, the largest organ of the body, f...
متن کاملذخیره در منابع من
با ذخیره ی این منبع در منابع من، دسترسی به آن را برای استفاده های بعدی آسان تر کنید
ژورنال
عنوان ژورنال: Journal of Biological Chemistry
سال: 1964
ISSN: 0021-9258
DOI: 10.1016/s0021-9258(18)91300-1